TfOH-catalyzed synthesis of 3-aryl isoindolinones via a tandem reaction.

نویسندگان

  • Jiaxing Hu
  • Hua-Li Qin
  • Wengang Xu
  • Junli Li
  • Fanglin Zhang
  • Hua Zheng
چکیده

A convenient metal-free method for the synthesis of 3-aryl isoindolinones via TfOH catalyzed aromatic C-H functionalization of electron-rich arenes with 2-formylbenzonitriles is developed. This process provided a new efficient strategy for the synthesis of isoindolinone derivatives in good to high yields and regioselectivities by forming two bonds.

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عنوان ژورنال:
  • Chemical communications

دوره 50 99  شماره 

صفحات  -

تاریخ انتشار 2014